Centrosome:db

Welcome to the centrosome:db database.

Centrosome:db contains a set of human genes encoding proteins that are localized in the centrosome, either as centrosome constituents or as centrosome visitors. Genes have been considered as centrosomal on the basis of different kinds of evidences including high-throughput proteomics assays, annotations in public databases and orthology relationships to centrosomal genes in closely related species (e.g. mouse). For each of these human genes we have compiled information from various sources such as Ensembl, OMIM, HPRD, SNPs, GeneOntology or Compara, among others. Orthologs in other species, ranging from yeast to mammals, have been also included in centrosome:db. The domain structure of all the associated peptides has been characterized based on the domain profiles of the Pfam and Superfamily databases (scanned with the RPS-BLAST program) and on the coiled-coil predictions of the COILS program. You can browse the database by:

• Searching with a gene name, database identifier or submmiting full text queries (uniprot, ensembl, hgnc, entrez, ipi and refseq identifiers are supported)
• Searching for a given domain in a particular specie (or all species)
• Accesing the orthology information related to a gene
• Comparing your own sequence with those in centrosome:db
• Retrieve all the human centrosomal genes based on their evidences

Orthology relationships for the full list of human genes can be downloaded clicking here

How to cite us:

Nogales-Cadenas, R., Abascal, F., Díez-Pérez, J., Carazo, JM, Pascual-Montano, A. CentrosomeDB: A Human Centrosomal Proteins Database. Nucleic Acids Research 2008; doi: 10.1093/nar/gkn815
[Medline] [On-line version]

Acknowledgements:

This work is supported by a scientific project named CENTROSOME_CM (CAM - P2006/Gen-0166) granted by the Government of Madrid, Spain (CAM)

© 2007/2008 UCM-CNB Bioinfo Unit | Centrosome CAM